Mechanism of the Central Effects of Dopamine and Metoclopramide on Aldosterone Regulation in the Rat

Kazuoki Kondo, Hiroshi Kawabe, Matsuhiko Hayashi, Masaki Fujimaki, Shusaku Nagahama, Takao Saruta

研究成果: Article査読

1 被引用数 (Scopus)

抄録

To investigate the mechanism of the central action of dopamine and its antagonist, metoclopramide, on the regulation of aldosterone, studies were performed in 54 conscious rats with and without bilateral nephrectomy. In normal and sham-operated rats, intracerebroventricular injection of dopamine resulted in a significant suppression of plasma renin activity and plasma aldosterone at 30 min, and intracerebroventricular injection of metoclopramide resulted in a significant elevation of plasma renin activity and plasma aldosterone at 30 min without altering the plasma corticosterone and potassium levels. In bilaterally nephrectomized rats, the plasma renin activity was significantly reduced and it did not respond to dopamine or metoclopramide. In these rats, intracerebroventricular injection of metoclopramide exerted no effect on the plasma aldosterone, but intracerebroventricular injection of dopamine increased the plasma aldosterone slightly. However, this increase was not statistically significant. These findings suggest that the dopaminergic system in the brain is involved in the regulation of aldosterone secretion, mainly with changes in the peripheral renin-angiotensin axis in rats.

本文言語English
ページ(範囲)543-549
ページ数7
ジャーナルEndocrinologia Japonica
30
4
DOI
出版ステータスPublished - 1983 1

ASJC Scopus subject areas

  • Endocrinology
  • Engineering(all)

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