Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Volker Spindler, Rüdiger Eming, Enno Schmidt, Masayuki Amagai, Sergei Grando, Marcel F. Jonkman, Andrew P. Kowalczyk, Eliane J. Müller, Aimee S. Payne, Carlo Pincelli, Animesh A. Sinha, Eli Sprecher, Detlef Zillikens, Michael Hertl, Jens Waschke

研究成果: Review article査読

70 被引用数 (Scopus)

抄録

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

本文言語English
ページ(範囲)32-37
ページ数6
ジャーナルJournal of Investigative Dermatology
138
1
DOI
出版ステータスPublished - 2018 1月

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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