Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing

Toshihiro Nishizawa, Hidekazu Suzuki

研究成果: Review article査読

59 被引用数 (Scopus)

抄録

Antibiotic resistance in Helicobacter pylori (H.pylori) is the main factor affecting the efficacy of current treatment methods against infection caused by this organism. The traditional culture methods for testing bacterial susceptibility to antibiotics are expensive and require 10-14 days. Since resistance to clarithromycin, fluoroquinolone, and tetracycline seems to be exclusively caused by specific mutations in a small region of the responsible gene, molecular methods offer an attractive alternative to the above-mentioned techniques. The technique of polymerase chain reaction (PCR) is an accurate and rapid method for the detection of mutations that confer antibiotic resistance. This review highlights the mechanisms of antibiotic resistance in H. pylori and the molecular methods for antibiotic susceptibility testing.

本文言語English
論文番号19
ジャーナルFrontiers in Molecular Biosciences
1
OCT
DOI
出版ステータスPublished - 2014 10月 24
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 生化学、遺伝学、分子生物学(その他)

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