Medical molecular morphology with imaging mass spectrometry

Yoshishige Kimura, Koji Tsutsumi, Yuki Sugiura, Mitsutoshi Setou

研究成果: Review article査読

12 被引用数 (Scopus)

抄録

Imaging mass spectrometry (IMS) is a two-dimensional mass spectrometry to visualize the spatial distribution of biomolecules that does not need either separation or purification of target molecules and enables us to monitor not only the identification of unknown molecules but also the localization of numerous molecules simultaneously. Among the ionization techniques, matrix-assisted laser desorption/ionization (MALDI) is one of those most generally used for IMS, which allows the analysis of numerous biomolecules ranging over wide molecular weights. At present, targets of IMS research have expanded to the imaging of small endogenous metabolites such as lipids, exogenous drug pharmacokinetics, exploring new disease markers, and other new scientific fields.

本文言語English
ページ(範囲)133-137
ページ数5
ジャーナルMedical Molecular Morphology
42
3
DOI
出版ステータスPublished - 2009 9月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 分子生物学

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