Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada; Kazuhiko Nakamura; Taeko Watabe; Osamu Ohno; Masaru Kawagoshi; Norihito Maru; Nobuo Uotsu; Tomohiro Chiba; Kohji Yamaguchi; Daisuke Uemura

doi:10.1271/bbb.110306

Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada, Kazuhiko Nakamura, Taeko Watabe, Osamu Ohno, Masaru Kawagoshi, Norihito Maru, Nobuo Uotsu, Tomohiro Chiba, Kohji Yamaguchi, Daisuke Uemura

研究成果: Article › 査読

10 被引用数 (Scopus)

抄録

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC ₅₀ values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

本文言語	English
ページ（範囲）	1628-1630
ページ数	3
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	75
号	8
DOI	https://doi.org/10.1271/bbb.110306
出版ステータス	Published - 2011
外部発表	はい

ASJC Scopus subject areas

バイオテクノロジー
分析化学
生化学
応用微生物学とバイオテクノロジー
分子生物学
有機化学

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10.1271/bbb.110306

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title = "Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus",

abstract = "The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.",

keywords = "Alkamide, Melanin biosynthesis inhibitor, Skin-whitening, α-melanocyte- stimulating hormone (α-MSH)",

author = "Masayoshi Yamada and Kazuhiko Nakamura and Taeko Watabe and Osamu Ohno and Masaru Kawagoshi and Norihito Maru and Nobuo Uotsu and Tomohiro Chiba and Kohji Yamaguchi and Daisuke Uemura",

note = "Funding Information: This work was supported in part by JSPS via grant-aid for scientific research (21221009 and 22603008).",

year = "2011",

doi = "10.1271/bbb.110306",

language = "English",

volume = "75",

pages = "1628--1630",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

AU - Yamada, Masayoshi

AU - Nakamura, Kazuhiko

AU - Watabe, Taeko

AU - Ohno, Osamu

AU - Kawagoshi, Masaru

AU - Maru, Norihito

AU - Uotsu, Nobuo

AU - Chiba, Tomohiro

AU - Yamaguchi, Kohji

AU - Uemura, Daisuke

N1 - Funding Information: This work was supported in part by JSPS via grant-aid for scientific research (21221009 and 22603008).

PY - 2011

Y1 - 2011

N2 - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

AB - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

KW - Alkamide

KW - Melanin biosynthesis inhibitor

KW - Skin-whitening

KW - α-melanocyte- stimulating hormone (α-MSH)

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U2 - 10.1271/bbb.110306

DO - 10.1271/bbb.110306

M3 - Article

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VL - 75

SP - 1628

EP - 1630

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 8

ER -

Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

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