Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada; Kazuhiko Nakamura; Taeko Watabe; Osamu Ohno; Masaru Kawagoshi; Norihito Maru; Nobuo Uotsu; Tomohiro Chiba; Kohji Yamaguchi; Daisuke Uemura

doi:10.1271/bbb.110306

Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

Masayoshi Yamada, Kazuhiko Nakamura, Taeko Watabe, Osamu Ohno, Masaru Kawagoshi, Norihito Maru, Nobuo Uotsu, Tomohiro Chiba, Kohji Yamaguchi, Daisuke Uemura

化学科

研究成果: Article

7 引用（Scopus）

抜粋

The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC ₅₀ values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

元の言語	English
ページ（範囲）	1628-1630
ページ数	3
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	75
発行部数	8
DOI	https://doi.org/10.1271/bbb.110306
出版物ステータス	Published - 2011 8 29

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

文献にアクセス

10.1271/bbb.110306

フィンガープリント Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Yamada, M., Nakamura, K., Watabe, T., Ohno, O., Kawagoshi, M., Maru, N., Uotsu, N., Chiba, T., Yamaguchi, K., & Uemura, D. (2011). Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus. Bioscience, Biotechnology and Biochemistry, 75(8), 1628-1630. https://doi.org/10.1271/bbb.110306

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title = "Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus",

abstract = "The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.",

keywords = "Alkamide, Melanin biosynthesis inhibitor, Skin-whitening, α-melanocyte- stimulating hormone (α-MSH)",

author = "Masayoshi Yamada and Kazuhiko Nakamura and Taeko Watabe and Osamu Ohno and Masaru Kawagoshi and Norihito Maru and Nobuo Uotsu and Tomohiro Chiba and Kohji Yamaguchi and Daisuke Uemura",

year = "2011",

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doi = "10.1271/bbb.110306",

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T1 - Melanin biosynthesis inhibitors from tarragon Artemisia dracunculus

AU - Yamada, Masayoshi

AU - Nakamura, Kazuhiko

AU - Watabe, Taeko

AU - Ohno, Osamu

AU - Kawagoshi, Masaru

AU - Maru, Norihito

AU - Uotsu, Nobuo

AU - Chiba, Tomohiro

AU - Yamaguchi, Kohji

AU - Uemura, Daisuke

PY - 2011/8/29

Y1 - 2011/8/29

N2 - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

AB - The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10- dynoic acid. The respective EC 50 values for melanin biosynthesis inhibition were 1.8 and 2.3μg/mL for 1 and 2.

KW - Alkamide

KW - Melanin biosynthesis inhibitor

KW - Skin-whitening

KW - α-melanocyte- stimulating hormone (α-MSH)

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