Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection

Ayako Nakajima, Masayuki Adachi, Michi Tanaka, Akira Suwa, Yoshihiro Yasuki, Hiroyuki Imaeda, Shinichi Inada

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.

本文言語English
ページ(範囲)1042-1046
ページ数5
ジャーナルInternal Medicine
42
10
DOI
出版ステータスPublished - 2003 10

ASJC Scopus subject areas

  • Internal Medicine

フィンガープリント 「Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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