Memory Impairment and Awareness of Memory Deficits in Early-Stage Alzheimer's Disease

Masaru Mimura, Madoka Yano

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Recognition memory of auditory verbal learning tests and awareness of memory deficits were examined in 24 individuals with earlystage Alzheimer's disease (AD) using a performance prediction-postdiction paradigm. Individuals with AD displayed impaired recognition memory, and recognition performance correlated positively with regional cerebral blood flow at rest in bilateral prefrontal areas and the left medial temporal area. In addition, underawareness of memory deficits was also marked even at this early stage. Individuals with AD retrospectively overestimated memory performance after actual performance, but appeared to benefit from feedback, and displayed intact online awareness of memory dysfunction, leading to normal prediction of the second session. However, individuals with AD failed to retrospectively incorporate incidents of memory failure into generalized self-belief systems. Brain/behavior correlational analyses suggest that the prefrontal cortex and posterior dorsomedial regions including the precuneus may be involved in self-awareness.

本文言語English
ページ(範囲)253-266
ページ数14
ジャーナルReviews in the Neurosciences
17
1-2
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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