Metabolic studies of galactosemic cataract

Hong Ming Cheng, Hua Xiong, Jing Xiong, Kazuo Tsubota

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.

本文言語English
ページ(範囲)345-349
ページ数5
ジャーナルExperimental Eye Research
51
4
DOI
出版ステータスPublished - 1990 10月
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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