Metabolome analysis based on capillary electrophoresis-mass spectrometry

Akiyoshi Hirayama, Masataka Wakayama, Tomoyoshi Soga

研究成果: Review article査読

72 被引用数 (Scopus)

抄録

Capillary electrophoresis-mass spectrometry (CE-MS) has emerged as a powerful new tool for comprehensive analysis of charged compounds. In this review, we provide a general description of the application of CE-MS in metabolome analysis, including the separation modes of CE, various interfaces and the mass spectrometers used. We also discuss strategies for sample pretreatment, data processing and peak identification, which are important processes in metabolome analysis. In addition, we highlight a number of new techniques to improve metabolite extraction, peak resolution and sensitivity. Finally, we provide some general conclusions and future perspectives.

本文言語English
ページ(範囲)215-222
ページ数8
ジャーナルTrAC - Trends in Analytical Chemistry
61
DOI
出版ステータスPublished - 2014 10月 1

ASJC Scopus subject areas

  • 分析化学
  • 分光学

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