Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis

Tetsuru Karasawa, Takafumi Saito, Yoshiyuki Ueno, Masahiro Sugimoto, Tomoyoshi Soga

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.

本文言語English
ページ(範囲)1575-1577
ページ数3
ジャーナルInternational Journal of Medical Sciences
10
11
DOI
出版ステータスPublished - 2013 9月 9

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル