Metastatic extramammary Paget's disease: Pathogenesis and novel therapeutic approach

Keitaro Fukuda, Takeru Funakoshi

研究成果: Short survey査読

27 被引用数 (Scopus)

抄録

Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.

本文言語English
論文番号38
ジャーナルFrontiers in Oncology
8
FEB
DOI
出版ステータスPublished - 2018 2 16
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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