Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension

Jinsuke Nishino, Kimiyo Yamashita, Hiromi Hashiguchi, Hideta Fujii, Takuya Shimazaki, Hiroshi Hamada

研究成果: Article査読

74 被引用数 (Scopus)

抄録

Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. These observations suggest that Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis.

本文言語English
ページ(範囲)1998-2008
ページ数11
ジャーナルEMBO Journal
23
9
DOI
出版ステータスPublished - 2004 5 5

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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