@article{3f4294e12ec947a78770d97918014827,
title = "Mexiletine shortens the QT interval in a pedigree of KCNH2 related long QT syndrome",
abstract = "A 23-year-old female had been suffering from recurrent syncopal episodes during sleep since her childhood. She had a family history of sudden death and her QTc interval was remarkably prolonged to 537 ms A Holter ECG revealed torsade de pointes, corresponding to syncope. She was started on mexiletine and her QTc interval shortened. Her symptoms were controlled after β-blockers and Ca-blockers were added. A genetic analysis with a next generation sequencer identified a frameshift mutation at the C terminus of the KCNH2 gene. Here we present a type 2 long QT syndrome case in which mexiletine was effective.",
keywords = "KCNH2, long QT syndrome, mexiletine, sudden death, torsade de pointes",
author = "Taishi Fujisawa and Yoshiyasu Aizawa and Yoshinori Katsumata and Kensuke Kimura and Kenji Hashimoto and Terumasa Yamashita and Hiroshi Miyama and Takehiro Kimura and Kenjiro Kosaki and Seiji Takatsuki and Wataru Shimizu and Keiichi Fukuda",
note = "Funding Information: We are grateful to Mr John Martin for editing this article. This work was supported by MEXT KAKENHI grant number 17K09524. Publisher Copyright: {\textcopyright} 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.",
year = "2020",
month = feb,
day = "1",
doi = "10.1002/joa3.12300",
language = "English",
volume = "36",
pages = "193--196",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "1",
}