Mexiletine shortens the QT interval in a pedigree of KCNH2 related long QT syndrome

Taishi Fujisawa, Yoshiyasu Aizawa, Yoshinori Katsumata, Kensuke Kimura, Kenji Hashimoto, Terumasa Yamashita, Hiroshi Miyama, Takehiro Kimura, Kenjiro Kosaki, Seiji Takatsuki, Wataru Shimizu, Keiichi Fukuda

研究成果: Article査読

1 被引用数 (Scopus)


A 23-year-old female had been suffering from recurrent syncopal episodes during sleep since her childhood. She had a family history of sudden death and her QTc interval was remarkably prolonged to 537 ms A Holter ECG revealed torsade de pointes, corresponding to syncope. She was started on mexiletine and her QTc interval shortened. Her symptoms were controlled after β-blockers and Ca-blockers were added. A genetic analysis with a next generation sequencer identified a frameshift mutation at the C terminus of the KCNH2 gene. Here we present a type 2 long QT syndrome case in which mexiletine was effective.

ジャーナルjournal of arrhythmia
出版ステータスPublished - 2020 2 1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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