Micro cell patterning technology by dielectrophoresis and application to regenerated cartilage

Yoshitaka Takeuchi, Shogo Miyata

研究成果: Article

抜粋

Recently, microfabrication tools have been utilized to quantify the role of the cellular microenvironment on cell activity and function. Improving tissue regeneration by cell culture on scaffold material will also require tools to control cellular organization in 3-dimentional (3-D) condition. Our objective was to improve cartilage tissue engineering using 3-D cell organization technology. In this study, we developed an anisotropic cartilaginous tissue by cell patterning within hydrogel slabs using dielectrophoretic (DEP) forces. Our data indicate that the embedded chondrocytes remained viable and reconstructed cartilaginous tissue along the patterned cell array. In conclusion, DEP cell patterning may become a useful approach for reconstructing anisotropic structure in cartilage regeneration.

元の言語English
ページ(範囲)3015-3020
ページ数6
ジャーナルNihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
76
発行部数771
DOI
出版物ステータスPublished - 2010 11

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ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

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