Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

Kenji Miyamoto, Shigeo Tsuchiya, Hiromichi Ohta

研究成果: Article査読

28 被引用数 (Scopus)

抄録

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids. Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing. Decarboxylation of α-fluoro-α- phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro- α-phenylacetic acid.

本文言語English
ページ(範囲)225-232
ページ数8
ジャーナルJournal of Fluorine Chemistry
59
2
DOI
出版ステータスPublished - 1992 11

ASJC Scopus subject areas

  • 生化学
  • 環境化学
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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