Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

研究成果: Article査読

111 被引用数 (Scopus)

抄録

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

本文言語English
ページ(範囲)1343-1346
ページ数4
ジャーナルTetrahedron Letters
32
10
DOI
出版ステータスPublished - 1991 3 4

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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