Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease

Kenya Honda, Koji Atarashi, Junko Nishio

研究成果: Chapter

1 被引用数 (Scopus)

抄録

The gastrointestinal tract represents a major gateway for infection by potential microbial pathogens, and, at the same time, contains hundreds of species of indigenous microbes. Thus, the intestinal immune system should actively react with potentially pathogenic microbes, while simultaneously remaining tolerant to or unaffected by the vast majority of commensal microbes. The recognition, and perhaps the discrimination, of pathogens and commensal microbes is primarily mediated by pathogen-associated molecular pattern (PAMP) receptors, including Toll-like receptors (TLRs) and nucleotide-binding domain (NOD)-like receptor (NLR) family proteins. The regulation of PAMP receptor signaling is critical in the maintenance of immune homeostasis in the intestine, and an aberrant signaling may result in inflammatory bowel diseases.

本文言語English
ホスト出版物のタイトルCrohn's Disease and Ulcerative Colitis
ホスト出版物のサブタイトルFrom Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
出版社Springer US
ページ97-110
ページ数14
ISBN(電子版)9781461409984
ISBN(印刷版)9781461409977
DOI
出版ステータスPublished - 2012 1 1
外部発表はい

ASJC Scopus subject areas

  • Medicine(all)

フィンガープリント 「Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル