Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease

Kenya Honda, Koji Atarashi, Junko Nishio

研究成果: Chapter

1 引用 (Scopus)

抜粋

The gastrointestinal tract represents a major gateway for infection by potential microbial pathogens, and, at the same time, contains hundreds of species of indigenous microbes. Thus, the intestinal immune system should actively react with potentially pathogenic microbes, while simultaneously remaining tolerant to or unaffected by the vast majority of commensal microbes. The recognition, and perhaps the discrimination, of pathogens and commensal microbes is primarily mediated by pathogen-associated molecular pattern (PAMP) receptors, including Toll-like receptors (TLRs) and nucleotide-binding domain (NOD)-like receptor (NLR) family proteins. The regulation of PAMP receptor signaling is critical in the maintenance of immune homeostasis in the intestine, and an aberrant signaling may result in inflammatory bowel diseases.

元の言語English
ホスト出版物のタイトルCrohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
出版者Springer US
ページ97-110
ページ数14
ISBN(印刷物)9781461409984, 9781461409977
DOI
出版物ステータスPublished - 2012 1 1
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Honda, K., Atarashi, K., & Nishio, J. (2012). Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease. : Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach (pp. 97-110). Springer US. https://doi.org/10.1007/978-1-4614-0998-4_6