Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

Yoshinaga Kawano, Madeline Edwards, Yiming Huang, Angelina M. Bilate, Leandro P. Araujo, Takeshi Tanoue, Koji Atarashi, Mark S. Ladinsky, Steven L. Reiner, Harris H. Wang, Daniel Mucida, Kenya Honda, Ivaylo I. Ivanov

研究成果: Article査読

11 被引用数 (Scopus)

抄録

How intestinal microbes regulate metabolic syndrome is incompletely understood. We show that intestinal microbiota protects against development of obesity, metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. High-fat, high-sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. Microbiota-induced Th17 cells afforded protection by regulating lipid absorption across intestinal epithelium in an IL-17-dependent manner. Diet-induced loss of protective Th17 cells was mediated by the presence of sugar. Eliminating sugar from high-fat diets protected mice from obesity and metabolic syndrome in a manner dependent on commensal-specific Th17 cells. Sugar and ILC3 promoted outgrowth of Faecalibaculum rodentium that displaced Th17-inducing microbiota. These results define dietary and microbiota factors posing risk for metabolic syndrome. They also define a microbiota-dependent mechanism for immuno-pathogenicity of dietary sugar and highlight an elaborate interaction between diet, microbiota, and intestinal immunity in regulation of metabolic disorders.

本文言語English
ページ(範囲)3501-3519.e20
ジャーナルCell
185
19
DOI
出版ステータスPublished - 2022 9月 15

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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