Microbiota in autoimmunity and tolerance

研究成果: Review article査読

72 被引用数 (Scopus)

抄録

The composition of a host's intestinal microbiota directs the type of mucosal and systemic immune responses by affecting the proportion and number of functionally distinct T cell subsets. In particular, the microbiota composition affects the differentiation of intestinal Th17 cells and Foxp3 + regulatory T cells, both of which play critical roles in maintaining mucosal barrier functions and in controlling immunological homeostasis. In this review, we discuss the recent advances in our understanding of how the intestinal microbiota affects T cell differentiation and host susceptibility to autoimmune disease.

本文言語English
ページ(範囲)761-768
ページ数8
ジャーナルCurrent Opinion in Immunology
23
6
DOI
出版ステータスPublished - 2011 12
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Microbiota in autoimmunity and tolerance」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル