Microbiota's influence on immunity

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Clostridium species belonging to clusters XIVa and IV are predominant organisms in the gut microbiota. They are known to affect various aspects of host biology, including the optimal breakdown of foods, competition with pathogenic microorganisms, maintenance of the intestinal epithelial barrier, and immune system development. We have recently shown that a defined mixture of 46 strains of mouse-derived Clostridium species belonging to clusters XIVa and IV affects the development and function of colonic Foxp3+ CD4+ regulatory T (Treg) cells in mice. Clostridium-induced Treg cells are likely to play a role in the maintenance of immune homeostasis in the gut.

元の言語English
ホスト出版物のタイトルInnate Immunity
ホスト出版物のサブタイトルResistance and Disease-Promoting Principles
出版者S. Karger AG
ページ43-47
ページ数5
4
ISBN(電子版)9783318023480
ISBN(印刷物)9783318023473
DOI
出版物ステータスPublished - 2013 6 5

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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