Microchip-based cellular biochemical systems for practical applications and fundamental research: From microfluidics to nanofluidics

Yan Xu, Kihoon Jang, Tadahiro Yamashita, Yo Tanaka, Kazuma Mawatari, Takehiko Kitamori

研究成果: Article査読

39 被引用数 (Scopus)

抄録

By combining cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale for both practical applications and fundamental research. On the microscale level, novel practical applications taking advantage of the unique capabilities of microfluidics have been accelerated in clinical diagnosis, food safety, environmental monitoring, and drug discovery. On the other hand, one important trend of this field is further downscaling of feature size to the 10 1-10 3 nm scale, which we call extended-nano space. Extended-nano space technology is leading to the creation of innovative nanofluidic cellular and biochemical tools for analysis of single cells at the single-molecule level. As a pioneering group in this field, we focus not only on the development of practical applications of cellular microchip devices but also on fundamental research to initiate new possibilities in the field. In this paper, we review our recent progress on tissue reconstruction, routine cell-based assays on microchip systems, and preliminary fundamental method for single-cell analysis at the single-molecule level with integration of the burgeoning technologies of extended-nano space. [Figure not available: see fulltext.]

本文言語English
ページ(範囲)99-107
ページ数9
ジャーナルAnalytical and bioanalytical chemistry
402
1
DOI
出版ステータスPublished - 2012 1月
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 生化学

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