Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

Ioannis K. Zervantonakis, Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, Roger D. Kamm

研究成果: Article査読

100 被引用数 (Scopus)

抄録

Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.

本文言語English
論文番号013406
ジャーナルBiomicrofluidics
5
1
DOI
出版ステータスPublished - 2011 3 23

ASJC Scopus subject areas

  • 分子生物学
  • 材料科学(全般)
  • 遺伝学
  • 凝縮系物理学
  • 物理化学および理論化学

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