Microfluidic experimental array using micro-rotation flow for producing size-controlled three-dimensional spheroids

Hiroki Ota, Taiga Kodama, Norihisa Miki

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

We propose a microfluidic experimental platform for producing size-controlled spheroids. Cells are collected to form a spheroid in chambers by micro-rotational flow in two minutes. The developed array could control the size of three-dimensional spheroids hydrodynamically with the standard deviations less than 19 % by varying the cell density of the medium without altering the device geometry. Using the developed perfusion system we experimentally observed that the sizes of formed spheroids remained constant for two days and that the detoxification enzyme, CYP1A1, activities increased.

本文言語English
ホスト出版物のタイトル2010 International Symposium on Micro-NanoMechatronics and Human Science
ホスト出版物のサブタイトルFrom Micro and Nano Scale Systems to Robotics and Mechatronics Systems, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010
ページ362-366
ページ数5
DOI
出版ステータスPublished - 2010 12 1
イベント21st Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010 - Nagoya, Japan
継続期間: 2010 11 72010 11 10

出版物シリーズ

名前2010 International Symposium on Micro-NanoMechatronics and Human Science: From Micro and Nano Scale Systems to Robotics and Mechatronics Systems, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010

Other

Other21st Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010
国/地域Japan
CityNagoya
Period10/11/710/11/10

ASJC Scopus subject areas

  • 電子工学および電気工学
  • 機械工学

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