Microfluidic experimental platform using micro-rotation flow for producing multiple size-controlled three-dimensional spheroids

Hiroki Ota, Taiga Kodama, Norihisa Miki

研究成果: Conference contribution

抜粋

We propose a microfluidic experimental platform for producing size-controlled spheroids. Cells are collected to form a spheroid in chambers by micro-rotational flow in two minutes. The developed array could control the size of three-dimensional spheroids hydrodynamically with the standard deviations less than 19 % by varying the cell density of the medium without altering the device geometry. Using the developed perfusion system we experimentally observed that the sizes of formed spheroids remained constant for two days and that the detoxification enzyme, CYP1A1, activities increased.

元の言語English
ホスト出版物のタイトル14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
ページ2080-2082
ページ数3
出版物ステータスPublished - 2010 12 1
イベント14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
継続期間: 2010 10 32010 10 7

出版物シリーズ

名前14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Netherlands
Groningen
期間10/10/310/10/7

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • これを引用

    Ota, H., Kodama, T., & Miki, N. (2010). Microfluidic experimental platform using micro-rotation flow for producing multiple size-controlled three-dimensional spheroids. : 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 2080-2082). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; 巻数 3).