Microfluidic Mixing of Polyamine with Acrolein Enables the Detection of the [4+4] Polymerization of Intermediary Unsaturated Imines: The Properties of a Cytotoxic 1,5-Diazacyclooctane Hydrogel

Ambara R. Pradipta, Ayumi Tsutsui, Akihiro Ogura, Shinya Hanashima, Yoshiki Yamaguchi, Almira Kurbangalieva, Katsunori Tanaka

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The [4+4] polymerization of an unsaturated imine, generated from the condensation of a polyamine and excess acrolein, was investigated. The polyamine was added by micropipet to acrolein, immediately yielding a mixture of the immiscible polymeric material. Microfluidic mixing was used to gradually form the soluble diazacyclooctane polymers. The polymerization reaction ultimately gave an insoluble cationic hydrogel that adhered strongly to anionic compounds on cell surfaces, including sialoglycan, and displayed a high cytotoxicity.

本文言語English
論文番号st-2014-u0541-l
ページ(範囲)2442-2446
ページ数5
ジャーナルSynlett
25
17
DOI
出版ステータスPublished - 2014 10 22
外部発表はい

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

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