Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Yukihiro Furusawa, Daisuke Takahashi, Yumiko Fujimura, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Infectious colitis is one of the most common health issues worldwide. Microfold (M) cells actively transport luminal antigens to gut-associated lymphoid tissue to induce IgA responses; however, it remains unknown whether M cells contribute to the induction of cellular immune responses. Here we report that M cell-dependent antigen transport plays a critical role in the induction of Th1, Th17, and Th22 responses against gut commensals in the steady state. The establishment of commensal-specific cellular immunity was a prerequisite for preventing bacterial dissemination during enteropathogenic Citrobacter rodentium infection. Therefore, M cell-null mice developed severe colitis with increased bacterial dissemination. This abnormality was associated with mucosal barrier dysfunction. These observations suggest that antigen transport by M cells may help maintain gut immune homeostasis by eliciting antigen-specific cellular immune responses.

本文言語English
ページ(範囲)679-690
ページ数12
ジャーナルMucosal Immunology
13
4
DOI
出版ステータスPublished - 2020 7 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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