TY - JOUR
T1 - Microinvasive Breast Carcinoma with Extensive Involvement of Level III Axillary Lymph Nodes
T2 - A Case Report
AU - Fujii, Kimihito
AU - Fukutomi, Takashi
AU - Tsuda, Hitoshi
AU - Akashi-Tanaka, Sadako
AU - Nanasawa, Takeshi
AU - Kanai, Yae
AU - Muramatsu, Yukio
PY - 1998
Y1 - 1998
N2 - A 44-year-old woman presented with a right huge axillary mass. Both mammography and ultrasonography revealed a primary cancer of 2.8 cm maximum diameter in the right breast and metastases in the axillary lymph nodes, both being confirmed by aspiration cytology as ductal carcinoma. Right standard radical mastectomy with level III axillary lymph node dissection was carried out. Pathologically, the tumor was diagnosed as ductal carcinoma in situ with microinvasion (DCISM), histologic grade 3. The area of stromal invasion measured 1 mm at its widest point. Sixteen of the 17 resected axillary lymph nodes contained metastases, including six level III lymph nodes. Immunohistochemical studies of the tumor revealed overexpression of p53 protein, but not that of c-erbB-2 protein. The frequency of lymph node metastases from DCISM is reported to be very low. Therefore, the present case with extensive involvement of level III lymph nodes was unusual.
AB - A 44-year-old woman presented with a right huge axillary mass. Both mammography and ultrasonography revealed a primary cancer of 2.8 cm maximum diameter in the right breast and metastases in the axillary lymph nodes, both being confirmed by aspiration cytology as ductal carcinoma. Right standard radical mastectomy with level III axillary lymph node dissection was carried out. Pathologically, the tumor was diagnosed as ductal carcinoma in situ with microinvasion (DCISM), histologic grade 3. The area of stromal invasion measured 1 mm at its widest point. Sixteen of the 17 resected axillary lymph nodes contained metastases, including six level III lymph nodes. Immunohistochemical studies of the tumor revealed overexpression of p53 protein, but not that of c-erbB-2 protein. The frequency of lymph node metastases from DCISM is reported to be very low. Therefore, the present case with extensive involvement of level III lymph nodes was unusual.
KW - Ductal carcinoma in situ with microinvasion
KW - Lymph node dissection
KW - Lymph node metastasis
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U2 - 10.1093/jjco/28.1.47
DO - 10.1093/jjco/28.1.47
M3 - Article
C2 - 9491142
AN - SCOPUS:0031611768
SN - 0368-2811
VL - 28
SP - 47
EP - 49
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
IS - 1
ER -
