MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma

Yusuke Yamamoto, Nobuyoshi Kosaka, Minoru Tanaka, Fumiaki Koizumi, Yae Kanai, Takayuki Mizutani, Yoshiki Murakami, Masahiko Kuroda, Atsushi Miyajima, Takashi Kato, Takahiro Ochiya

研究成果: Article査読

183 被引用数 (Scopus)

抄録

We identified that microRNA expression changed dynamically during liver development and found that miR-500 is an oncofetal miRNA in liver cancer. miR-500 was abundantly expressed in several human liver cancer cell lines and 45% of human hepatocellular carcinoma (HCC) tissue. Most importantly, an increased amount of miR-500 was found in the sera of the HCC patients. In fact, miR-500 levels in sera of the HCC patients returned to normal after the surgical treatment in three HCC patients. Our findings reveal that diverse changes of miRNAs occur during liver development and, one of these, miR-500 is an oncofetal miRNA relevant to the diagnosis of human HCC.

本文言語English
ページ(範囲)529-538
ページ数10
ジャーナルBiomarkers
14
7
DOI
出版ステータスPublished - 2009
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 臨床生化学
  • 健康、毒物学および変異誘発

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