Midkine gene transfer in brain infarction

Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita, Yasuhiro Kumai

研究成果: Chapter

抄録

Cerebrovascular disease is the leading cause of death and disability in Japan and most Western countries. Gene transfer techniques may be applicable to the treatment of serious types of stroke, since several experimental studies have revealed the usefulness of gene therapy in the prevention of vasospasm after subarachnoid hemorrhage, reduction of infarct size and improvement of neuronal functions. Midkine is reported to have anti-apoptotic effects, and the gene transfer of midkine to the ischemic brain may provide neuroprotective effects. Furthermore, chemotactic effects of midkine could be utilized for the neurogenesis and functional recovery. We describe the novel possibility of the stroke treatment using midkine gene transfer.

本文言語English
ホスト出版物のタイトルMidkine
ホスト出版物のサブタイトルFrom Embryogenesis to Pathogenesis and Therapy
出版社Springer Netherlands
ページ153-163
ページ数11
ISBN(電子版)9789400742345
ISBN(印刷版)9400742339, 9789400742338
DOI
出版ステータスPublished - 2012 11 1

ASJC Scopus subject areas

  • Medicine(all)

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