TY - JOUR
T1 - Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1 taxonomy, fermentation, isolation and biological activities
AU - Nakae, K.
AU - Yoshimoto, Y.
AU - Sawa, T.
AU - Homma, Y.
AU - Hamada, M.
AU - Takeuchi, T.
AU - Imoto, M.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
AB - A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
UR - http://www.scopus.com/inward/record.url?scp=0033757121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033757121&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.53.1130
DO - 10.7164/antibiotics.53.1130
M3 - Article
C2 - 11132958
AN - SCOPUS:0033757121
SN - 0021-8820
VL - 53
SP - 1130
EP - 1136
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 10
ER -
