Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta

Shimpei Sumimoto, Masayuki Kobayashi, Rio Sato, Seiichi Shinomiya, Arihiro Iwasaki, Shoichiro Suda, Toshiaki Teruya, Toshiyasu Inuzuka, Osamu Ohno, Kiyotake Suenaga

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC 50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.

本文言語English
ページ(範囲)1187-1190
ページ数4
ジャーナルOrganic Letters
21
4
DOI
出版ステータスPublished - 2019 2月 15

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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