@article{9e29739437ef497c9ee92ae960424dab,
title = "Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta",
abstract = " Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC 50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species. ",
author = "Shimpei Sumimoto and Masayuki Kobayashi and Rio Sato and Seiichi Shinomiya and Arihiro Iwasaki and Shoichiro Suda and Toshiaki Teruya and Toshiyasu Inuzuka and Osamu Ohno and Kiyotake Suenaga",
note = "Funding Information: This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16H03285 and 17H05450). We thank Kaneka Corporation for their gift of (S)-Roche ester. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = feb,
day = "15",
doi = "10.1021/acs.orglett.9b00135",
language = "English",
volume = "21",
pages = "1187--1190",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "4",
}
