Misprocessed tRNA response targets piRNA clusters

Soichiro Yamanaka, Haruhiko Siomi

研究成果: Short survey査読

5 被引用数 (Scopus)

抄録

Germline PIWI-interacting RNA (piRNA) clusters have a characteristic transcriptional status; although they do not have their own promoters, both genomic strands are transcribed, while splicing and 3' processing signals are neglected. How this transcription is maintained remains unknown. Molla-Herman et al (2015) discovered that mutations in a tRNA processing factor cause the loss of transcription at some piRNA clusters, leading to sterility in Drosophila melanogaster. This defect in piRNA cluster transcription is restored by mutations in genes required for the DNA damage checkpoint or replication.

本文言語English
ページ(範囲)2988-2989
ページ数2
ジャーナルEMBO Journal
34
24
DOI
出版ステータスPublished - 2015 12 14

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

フィンガープリント

「Misprocessed tRNA response targets piRNA clusters」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル