Missense mutations of the BRAF gene in human lung adenocarcinoma

Katsuhiko Naoki, Tzu Hsiu Chen, William G. Richards, David J. Sugarbaker, Matthew Meyerson

研究成果: Article査読

257 被引用数 (Scopus)

抄録

Mutations of the BRAF protein serine/threonine kinase gene have recently been identified in a variety of human cancers, most notably melanomas. We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. Analysis of BRAF sequence from 127 primary human lung adenocarcinomas revealed mutations in two tumor specimens, one in exon 11 (G465V), and a second in exon 15 (L596R). These specimens belong to the same adenocarcinoma subgroup as defined by clustering of gene expression data. BRAF may provide a target for anticancer chemotherapy in a subset of lung adenocarcinoma patients.

本文言語English
ページ(範囲)7001-7003
ページ数3
ジャーナルCancer Research
62
23
出版ステータスPublished - 2002 12 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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