抄録
Mitochondria is the major site of energy production in cells, therefore, mitochondrial abnormality may affect functions of organs including the brain, which constantly requires high levels of energy consumption. Previous studies have suggested a role of mitochondria and their DNA polymorphisms in neuro-psychiatric disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia and bipolar mood disorder. Thus, we hypothesized that mitochondrial DNA polymorphisms might be related with the development of personality. The present study investigated a role of two mitochondrial DNA polymorphisms, the C5178A and A10398G, in personality traits evaluated using the NEO PI-R scores in 238 healthy Japanese volunteers. Subjects with the 5178A genotype showed significantly higher extraversion score than those with the 5178C genotype (P = 0.027), while no significant association was observed between the C5178A polymorphism and other scores. No significant association was found between the A10398G polymorphism and any scores. Regarding the 5178-10398 haplotype, the score of extraversion, not other scores, was significantly associated with the A-G haplotype (P = 0.042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 76-79 |
| ページ数 | 4 |
| ジャーナル | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| 巻 | 128 B |
| 発行部数 | 1 |
| 出版物ステータス | Published - 2004 7 1 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Genetics(clinical)
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
これを引用
Mitochondrial DNA polymorphisms and extraversion. / Kato, Chieko; Umekage, Tadashi; Tochigi, Mamoru; Otowa, Takeshi; Hibino, Hiroyuki; Ohtani, Toshiyuki; Kohda, Kazuhisa; Kato, Nobumasa; Sasaki, Tsukasa.
：: American Journal of Medical Genetics - Neuropsychiatric Genetics, 巻 128 B, 番号 1, 01.07.2004, p. 76-79.研究成果: Article
}
TY - JOUR
T1 - Mitochondrial DNA polymorphisms and extraversion
AU - Kato, Chieko
AU - Umekage, Tadashi
AU - Tochigi, Mamoru
AU - Otowa, Takeshi
AU - Hibino, Hiroyuki
AU - Ohtani, Toshiyuki
AU - Kohda, Kazuhisa
AU - Kato, Nobumasa
AU - Sasaki, Tsukasa
PY - 2004/7/1
Y1 - 2004/7/1
N2 - Mitochondria is the major site of energy production in cells, therefore, mitochondrial abnormality may affect functions of organs including the brain, which constantly requires high levels of energy consumption. Previous studies have suggested a role of mitochondria and their DNA polymorphisms in neuro-psychiatric disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia and bipolar mood disorder. Thus, we hypothesized that mitochondrial DNA polymorphisms might be related with the development of personality. The present study investigated a role of two mitochondrial DNA polymorphisms, the C5178A and A10398G, in personality traits evaluated using the NEO PI-R scores in 238 healthy Japanese volunteers. Subjects with the 5178A genotype showed significantly higher extraversion score than those with the 5178C genotype (P = 0.027), while no significant association was observed between the C5178A polymorphism and other scores. No significant association was found between the A10398G polymorphism and any scores. Regarding the 5178-10398 haplotype, the score of extraversion, not other scores, was significantly associated with the A-G haplotype (P = 0.042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait.
AB - Mitochondria is the major site of energy production in cells, therefore, mitochondrial abnormality may affect functions of organs including the brain, which constantly requires high levels of energy consumption. Previous studies have suggested a role of mitochondria and their DNA polymorphisms in neuro-psychiatric disorders, including Alzheimer's disease, Parkinson's disease, schizophrenia and bipolar mood disorder. Thus, we hypothesized that mitochondrial DNA polymorphisms might be related with the development of personality. The present study investigated a role of two mitochondrial DNA polymorphisms, the C5178A and A10398G, in personality traits evaluated using the NEO PI-R scores in 238 healthy Japanese volunteers. Subjects with the 5178A genotype showed significantly higher extraversion score than those with the 5178C genotype (P = 0.027), while no significant association was observed between the C5178A polymorphism and other scores. No significant association was found between the A10398G polymorphism and any scores. Regarding the 5178-10398 haplotype, the score of extraversion, not other scores, was significantly associated with the A-G haplotype (P = 0.042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait.
KW - Association study
KW - Extraversion
KW - Mitochondrial DNA
KW - Personality traits
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=3042803817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042803817&partnerID=8YFLogxK
M3 - Article
C2 - 15211636
AN - SCOPUS:3042803817
VL - 128 B
SP - 76
EP - 79
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 1
ER -