Mitosis in Beating Cardiac Muscle Cells from Newt Embryos In Vitro

HIROYUKI KANEKO, ABE SHIN‐ICHI, SHIZUO ITO

研究成果: Article

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Cardiac muscle cells from newt embryos were cultured at relatively low cell density. Within 10 days in culture, 2 cell types (spindle and flat type) were distinguished both among beating and non‐beating cells. Mitosis in single beating cells was frequently observed both in spindle and flat cells. Some cells maintained almost constant contractile activities throughout the mitotic stages, while the others transiently stopped beating during mitosis, which accords well to the case in chick embryos (1). Ultra‐thin section shows the presence of myofibril's structure in a dividing cell, as shown in newborn rats (2, 3, 4), chick embryos (1, 5, 6, 7) and adult newts (8, 9). As a consequence of mitosis, 3 types (spindle, flat and mixed type) of beating colonies developed after 34 weeks in culture. Cell proliferation was accompanied with pulsation and could be directly pursued till the 4th division, suggesting that differentiated myocardiac cells with myofibrils proliferate by their mitoses in vivo, maintaining rhythmic contraction.

元の言語English
ページ(範囲)237-244
ページ数8
ジャーナルDevelopment, Growth & Differentiation
23
発行部数3
DOI
出版物ステータスPublished - 1981
外部発表Yes

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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