Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path

David H. Gire, Kevin M. Franks, Joseph D. Zak, Kenji F. Tanaka, Jennifer D. Whitesell, Abigail A. Mulligan, René Hen, Nathan E. Schoppa

研究成果: Article査読

111 被引用数 (Scopus)

抄録

Within the olfactory system, information flow from the periphery onto output mitral cells (MCs) of the olfactory bulb (OB) has been thought to be mediated by direct synaptic inputs from olfactory sensory neurons (OSNs). Here, we performed patch-clamp measurements in rat and mouse OB slices to investigate mechanisms of OSN signaling onto MCs, including the assumption of a direct path, using electrical and optogenetic stimulation methods that selectively activated OSNs. We found that MCs are in fact not typically activated by direct OSN inputs and instead require a multistep, diffuse mechanism involving another glutamatergic cell type, the tufted cells. The preference for a multistep mechanism reflects the fact that signals arising from direct OSN inputs are drastically shunted by connexin 36-mediated gap junctions on MCs, but not tufted cells. An OB circuit with tufted cells intermediate between OSNs and MCs suggests that considerable processing of olfactory information occurs before its reaching MCs.

本文言語English
ページ(範囲)2964-2975
ページ数12
ジャーナルJournal of Neuroscience
32
9
DOI
出版ステータスPublished - 2012 2月 29
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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