Mixed Infection of Cytomegalovirus and Pulmonary Nocardiosis Caused by Nocardia elegans Diagnosed Using Nanopore Sequencing Technology

Chie Watanabe, Yoshifumi Kimizuka, Yuji Fujikura, Takaaki Hamamoto, Akira Watanabe, Takashi Yaguchi, Tomoya Sano, Ryohei Suematsu, Yoshiki Kato, Jun Miyata, Susumu Matsukuma, Akihiko Kawana

研究成果: Article査読

抄録

A 69-year-old woman who had undergone renal transplantation and was receiving sulfamethoxazole/trimethoprim (ST) developed pulmonary nocardiosis. To our knowledge, this is the first report of the identification of Nocardia elegans using nanopore sequencing, supported by 16S rDNA capillary sequencing findings. Chest computed tomography performed after ST initiation revealed significant improvement of the pulmonary shadows compared to previous findings. We herein report the value of nanopore sequencing for rapid identification of rare pathogens, such as Nocardia elegans. Furthermore, our findings suggest that Nocardia may infect even patients receiving ST, which is currently the most effective prophylactic drug.

本文言語English
ページ(範囲)1613-1617
ページ数5
ジャーナルInternal Medicine
61
10
DOI
出版ステータスPublished - 2022
外部発表はい

ASJC Scopus subject areas

  • 内科学

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