Rheumatoid arthritis (RA) is characterized by chronic proliferative synovitis, in which various proteinases are produced and attack the articular cartilage. Among the proteinases, matrix metalloproteinases (MMPs) may play a major role in the degradation of the extracellular matrix macromolecules in RA cartilage. However, recent studies have demonstrated the possible involvement of MMP-related metalloproteinases, i.e. a disintegrin and metalloproteinases (ADAMs) in the degradation. In the present article, we review recent information about the MMP and ADAM families and their implications for cartilage destruction in RA.
|出版ステータス||Published - 2004 12月 1|
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