TY - JOUR
T1 - Modeling neurodevelopment in a dish with pluripotent stem cells
AU - Imaizumi, Kent
AU - Okano, Hideyuki
N1 - Funding Information:
The authors are grateful to Dr. Mitsuru Ishikawa for advice and discussion. This work was supported by funding from Japan Agency for Medical Research and Development (AMED) (Grant Number JP20bm0204001, JP20bm0804003) to H.O., Japan Society for the Promotion of Science (JSPS) (Grant Number JP19K16927) and Japan Science Society (Sasakawa Scientific Research Grant) to K.I.
Publisher Copyright:
© 2020 The Authors. Development, Growth & Differentiation published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Developmental Biologists
PY - 2021/1
Y1 - 2021/1
N2 - Pluripotent stem cells (PSCs) can differentiate into all cell types in the body, and their differentiation procedures recapitulate the developmental processes of embryogenesis. Focusing on neurodevelopment, we describe here the application of knowledge gained from embryology to the neural induction of PSCs. Furthermore, PSC-based neural modeling provides novel insights into neurodevelopmental processes. In particular, human PSC cultures are a powerful tool for the study of human-specific neurodevelopmental processes and could even enable the elucidation of the mechanisms of human brain evolution. We also discuss challenges and potential future directions in further improving PSC-based neural modeling.
AB - Pluripotent stem cells (PSCs) can differentiate into all cell types in the body, and their differentiation procedures recapitulate the developmental processes of embryogenesis. Focusing on neurodevelopment, we describe here the application of knowledge gained from embryology to the neural induction of PSCs. Furthermore, PSC-based neural modeling provides novel insights into neurodevelopmental processes. In particular, human PSC cultures are a powerful tool for the study of human-specific neurodevelopmental processes and could even enable the elucidation of the mechanisms of human brain evolution. We also discuss challenges and potential future directions in further improving PSC-based neural modeling.
KW - human-specific neurodevelopment
KW - neural specification
KW - pluripotent stem cell
KW - regional patterning
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U2 - 10.1111/dgd.12699
DO - 10.1111/dgd.12699
M3 - Article
C2 - 33141454
AN - SCOPUS:85096667649
SN - 0012-1592
VL - 63
SP - 18
EP - 25
JO - Development, growth & differentiation
JF - Development, growth & differentiation
IS - 1
ER -