Moderate hypoglycemia induces ultrastructural changes in perivascular nerve terminals of cat cerebral arteries

Kazuo Isozumi, Yasuo Fukuuchi, Atsuo Koto, Norihiro Suzuki, Yoshio Izumi, Yoko Tsuzuki

研究成果: Article

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A quantitative morphological analysis of the perivascular nerve terminals of cerebral arteries during moderate hypoglycemia was performed. 5-Hydroxydopamine (5-OHDA) was applied to discriminate dense-cored vesicles, related to noradrenaline, and clear vesicles, related to acetylcholine, under the electron microscope. Five hypoglycemic and 5 normoglycemic cats, all receiving 5-OHDA, were compared. In both the middle cerebral artery and vertebral artery, the dense-cored vesicles were significantly smaller and clear vesicles were significantly larger in hypoglycemia than in normoglycemia. These morphological changes in the vesicles may indicate hyperactivity of the sympathetic system and hypoactivity of the parasympathetic system of the cerebral vessels during hypoglycemia.

元の言語English
ページ(範囲)67-70
ページ数4
ジャーナルNeuroscience Letters
134
発行部数1
DOI
出版物ステータスPublished - 1991 12 16

ASJC Scopus subject areas

  • Neuroscience(all)

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