Modification of striatal arginine and citrulline metabolism by nitric oxide synthase inhibitors

Kouichi Ohta, Kunio Shimazu, Satoru Komatsumoto, Nobuo Araki, Mamoru Shibata, Yasuo Fukuuchi

研究成果: Article査読

33 被引用数 (Scopus)

抄録

The effects of NG-substituted L-arginine (ARG) analogues on striatal ARG and citrulline (CIT) levels were investigated using in vivo microdialysis technique. A microdialysis probe was implanted into the striatum of anaesthetized Sprague-Dawley rats. Direct intrastriatal perfusion with 1 mM NG-nitro-L-arginine methyl ester (n = 8) increased striatal ARG release and decreased CIT release, suggesting suppressed NO synthase activity in the tissue. On the other hand, 1 mM NG-monomethyl-L-argi-nine (L-NMMA) (n = 6) evoked a persistent increase in both ARG and CIT. Considering that 4-320 μM L-ARG (n = 8) failed to increase CIT formation, CIT seems to be synthesized in the striatal tissue from L-NMMA by the enzyme that has been demonstrated in the kidney and aortic endothelium (NG, NG-dimethylarginine dimethyl-aminohydrolase).

本文言語English
ページ(範囲)766-768
ページ数3
ジャーナルNeuroReport
5
7
DOI
出版ステータスPublished - 1994 3

ASJC Scopus subject areas

  • 神経科学(全般)

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