Modulators of the multidrug-transporter, P-glycoprotein, exist in the human plasma

Misako Ichikawa, Akihiko Yoshimura, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Shin ichi Akiyama

研究成果: Article査読

24 被引用数 (Scopus)

抄録

P-glycoprotein (P-gp) is thought to mediate the transport of anticancer drugs and to be responsible for the multidrug-resistant (MDR) phenotype. P-gp is also expressed in normal human tissues, such as the adrenal gland, kidney, liver, colon and capillary endothelium of the brain. However, the function and transporting substrates of P-gp in normal tissues are still not understood. This paper explains that some compounds in the human plasma can modulate the transporting activity of P-gp. A partially purified fraction from the human plasma enhanced the accumulation of anti-cancer agents in MDR cells. This fraction inhibited the efflux of vinblastine from MDR cells, and also inhibited the photoaffinity labeling of P-gp with azidopine as effectively as vinblastine, quinidine and cepharanthine. The compounds in this purified fraction may be physiological substrates of P-gp and can probably overcome MDR.

本文言語English
ページ(範囲)74-80
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
166
1
DOI
出版ステータスPublished - 1990 1月 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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