Modulatory role of vasopressin in secretion of atrial natriuretic polypeptide in conscious rats

Hiroshi Itoh, Kazuwa Nakao, Takayuki Yamada, Narito Morii, Shozo Shiono, Akira Sugawara, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Goro Katsuura, Nasami Eigyo, Akira Matsushita, Hiroo Imura

研究成果: Article査読

35 被引用数 (Scopus)

抄録

To investigate whether vasopressin is involved in the secretory mechanism of atrial natriuretic polypeptide (ANP), effects of arginine-vasopressin (AVP) administered iv on plasma ANP levels were studied in conscious, unrestrained rats. The administration of 100 ng and 1 ug of AVP caused a dose-dependent increase of the plasma ANP level, which was blocked by a V1-receptor antagonist of AVP, and was attenuated by 5 ml blood volume reduction before the stimulation. The injection of less than 10 ng of AVP induced no significant effects on ANP secretion. However, the administration of 5 ng of AVP significantly enhanced ANP secretion induced by intravascular volume expansion with 3 ml saline infusion. These results suggest the possible physiological significance of AVP as a modulator rather than a direct stimulator of ANP secretion from the heart.

本文言語English
ページ(範囲)2186-2188
ページ数3
ジャーナルEndocrinology
120
5
DOI
出版ステータスPublished - 1987 5
外部発表はい

ASJC Scopus subject areas

  • Endocrinology

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