Molecular abnormalities of T-cells in systemic lupus erythematosus

Tsutomu Takeuchi, Kensei Tsuzaka, Hideto Kameda, Kouichi Amano

研究成果: Review article査読

抄録

Abstract: Substantial evidence supports that T-cells play a central role in the pathogenesis of systemic lupus erythematosus (SLE). To explore the molecular basis of the defective function of SLE T-cells, we focused on the signal transduction system via T-cell antigen receptor (TCR) in peripheral blood T-cells from SLE patients. Comprehensive analysis to identify the molecules responsible for the defects showed the expression of the TCR ζ chain was attenuated, or absent in more than half of SLE patients. Moreover, the aberrant transcripts of the TCR ζ chain, including spliced variants lacking exon 7 and with a short 3′-UTR, were detected in SLE T-cells. Although attenuated expression of the TCR ζ chain is also observed in patients with cancers, infections, and other autoimmune diseases, sustained attenuation of TCR ζ expression and aberrant transcripts are only observed in SLE. In this review we discuss the unique features of the TCR ζ defects in SLE.

本文言語English
ページ(範囲)365-371
ページ数7
ジャーナルAPLAR Journal of Rheumatology
9
4
DOI
出版ステータスPublished - 2006 12 1
外部発表はい

ASJC Scopus subject areas

  • リウマチ学

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