Molecular analysis of the h-warts/LATS1 gene in human breast cancer.

N. Morinaga, Y. Shitara, Y. Yanagita, T. Koida, M. Kimura, T. Asao, I. Kimijima, S. Takenoshita, T. Hirota, H. Saya, H. Kuwano

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.

本文言語English
ページ(範囲)1125-1129
ページ数5
ジャーナルInternational journal of oncology
17
6
出版ステータスPublished - 2000 12月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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