抄録
Loss of heterozygosity (LOH) on chromosome 6q is often observed in breast cancer, suggesting the existence of a putative tumor suppressor. Recently, a human homolog of the Drosophila warts tumor suppressor gene, h-warts/LATS1, was identified and mapped at chromosome 6q24-25.1. Mutation analysis of the h-warts/LATS1 was performed using 25 breast cancer tissues by RT-PCR SSCP analysis. Although LOH of the h-warts/LATS1 was found in one patient, no mutations were found. Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1125-1129 |
| ページ数 | 5 |
| ジャーナル | International journal of oncology |
| 巻 | 17 |
| 号 | 6 |
| 出版ステータス | Published - 2000 12月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
