Molecular cloning and expression of Xenopus laevis Requiem cDNA

Masahiro Konishi, Yoshiki Hiraoka, Motoyuki Ogawa, Yukinao Sakai, Hiromasa Ishii, Sadakazu Aiso

研究成果: Article

5 引用 (Scopus)


Requiem is an apoptosis-associated gene, which was originally identified in mouse (T.G. Gabig et al., J. Biol. Chem. 269 (1994) 29515-29519). In this study, we isolated five independent cDNA clones for frog Requiem (xReq) from Xenopus laevis ovary. Sequence analysis of the multiple cDNAs has suggested that Xenopus genome contains at least two non-allelic copies of the xReq gene. The amino acid sequence deduced from the cDNAs contained a single Kruppel-type zinc-finger motif and two PHD-finger motifs. Northern analysis revealed that the ovary expressed xReq transcripts with different sizes.

ジャーナルBiochimica et Biophysica Acta - Gene Structure and Expression
出版物ステータスPublished - 1999 4 14

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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