TY - JOUR
T1 - Molecular design, chemical synthesis and biological activity of artificial and DNA photocleaving carbohydrate-intercalator hybrids
AU - Toshima, Kazunobu
PY - 2005/4
Y1 - 2005/4
N2 - Studies of the interaction between the small molecules and DNA, especially the effects of the structural characteristics of the small molecules on the DNA interaction, are very important for the design of DNA targeting new drugs. In this context, the development of photochemical DNA cleaving agents, which selectively cleave DNA by irradiation with light of a specific wavelength under mild conditions and without any additives such as metals and reducing agents, is very interesting from chemical and biological standpoints and offers considerable potential in medicine especially in the post-genome era. In this article, the molecular design, chemical synthesis, DNA photocleaving property and photo-selective cytotoxicity of such novel and artificial light activatable DNA cleaving agents, which consist of DNA intercalator and carbohydrate, are described.
AB - Studies of the interaction between the small molecules and DNA, especially the effects of the structural characteristics of the small molecules on the DNA interaction, are very important for the design of DNA targeting new drugs. In this context, the development of photochemical DNA cleaving agents, which selectively cleave DNA by irradiation with light of a specific wavelength under mild conditions and without any additives such as metals and reducing agents, is very interesting from chemical and biological standpoints and offers considerable potential in medicine especially in the post-genome era. In this article, the molecular design, chemical synthesis, DNA photocleaving property and photo-selective cytotoxicity of such novel and artificial light activatable DNA cleaving agents, which consist of DNA intercalator and carbohydrate, are described.
KW - Antitumor agent
KW - Cancer cell
KW - Carbohydrate
KW - Cytotoxicity
KW - DNA cleavage
KW - Intercalator
KW - Neocarzinostatin chromophore
KW - Photoirradiation
KW - Quinoxaline
UR - http://www.scopus.com/inward/record.url?scp=20444364870&partnerID=8YFLogxK
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U2 - 10.5059/yukigoseikyokaishi.63.325
DO - 10.5059/yukigoseikyokaishi.63.325
M3 - Review article
AN - SCOPUS:20444364870
VL - 63
SP - 325
EP - 338
JO - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
JF - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
SN - 0037-9980
IS - 4
ER -