Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents

Kazunobu Toshima; Tomonori Kimura; Ryusuke Takano; Tomohiro Ozawa; Akiko Ariga; Yutaka Shima; Kazuo Umezawa; Shuichi Matsumura

doi:10.1016/S0040-4020(03)00820-2

Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents

Kazunobu Toshima, Tomonori Kimura, Ryusuke Takano, Tomohiro Ozawa, Akiko Ariga, Yutaka Shima, Kazuo Umezawa, Shuichi Matsumura

応用化学科

研究成果: Article › 査読

22 被引用数 (Scopus)

抄録

The quinoxaline moiety in antitumor quinoxaline antibiotics cleaved double stranded DNA at the 5′ side guanine of the 5′-GG-3′ site upon irradiation with UV light with a long wavelength and without any additive. The quinoxaline-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the quinoxaline-carbohydrate hybrids exhibited strong and selective cytotoxicity against cancer cells with photoirradiation.

本文言語	English
ページ（範囲）	7057-7066
ページ数	10
ジャーナル	Tetrahedron
巻	59
号	35
DOI	https://doi.org/10.1016/S0040-4020(03)00820-2
出版ステータス	Published - 2003 8 25

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

文献へのアクセス

10.1016/S0040-4020(03)00820-2

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引用スタイル

Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents. / Toshima, Kazunobu; Kimura, Tomonori; Takano, Ryusuke; Ozawa, Tomohiro; Ariga, Akiko; Shima, Yutaka; Umezawa, Kazuo; Matsumura, Shuichi.

In: Tetrahedron, Vol. 59, No. 35, 25.08.2003, p. 7057-7066.

研究成果: Article › 査読

Toshima, Kazunobu ; Kimura, Tomonori ; Takano, Ryusuke ; Ozawa, Tomohiro ; Ariga, Akiko ; Shima, Yutaka ; Umezawa, Kazuo ; Matsumura, Shuichi. / Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents. In: Tetrahedron. 2003 ; Vol. 59, No. 35. pp. 7057-7066.

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AU - Umezawa, Kazuo

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