@article{a6f497c5a81f4366b80c75c1b6910202,
title = "Molecular design, chemical synthesis and biological evaluation of quinoxaline-carbohydrate hybrids as novel and selective photo-induced DNA cleaving and cytotoxic agents",
abstract = "The quinoxaline moiety in antitumor quinoxaline antibiotics cleaved double stranded DNA at the 5′ side guanine of the 5′-GG-3′ site upon irradiation with UV light with a long wavelength and without any additive. The quinoxaline-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the quinoxaline-carbohydrate hybrids exhibited strong and selective cytotoxicity against cancer cells with photoirradiation.",
keywords = "Carbohydrate, Cytotoxicity, DNA photocleavage, Quinoxaline",
author = "Kazunobu Toshima and Tomonori Kimura and Ryusuke Takano and Tomohiro Ozawa and Akiko Ariga and Yutaka Shima and Kazuo Umezawa and Shuichi Matsumura",
note = "Funding Information: This research was partially supported by Grant-in-Aid for the 21st Century COE program {\textquoteleft}KEIO Life Conjugate Chemistry{\textquoteright} and for General Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan, and Takeda Science Foundation.",
year = "2003",
month = aug,
day = "25",
doi = "10.1016/S0040-4020(03)00820-2",
language = "English",
volume = "59",
pages = "7057--7066",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "35",
}
