The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.
|出版ステータス||Published - 2004 8月 23|
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