Molecular design, chemical synthesis, and biological evaluation of anthracene-carbohydrate hybrids as novel DNA photocleaving and photoselective cytotoxic agents

Kazunobu Toshima, Masashi Hasegawa, Junji Shimizu, Shuichi Matsumura

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The anthracene-carbohydrate hybrids were designed and synthesized via an effective glycosidation. The hybrids cleaved double stranded DNA at the guanine site upon irradiation with UV light of a long wavelength and without any additive. The anthracene-carbohydrate hybrid system was very effective for the DNA cleavage. Furthermore, the anthracene-carbohydrate hybrids exhibited photoselective and strong cytotoxicity against cancer cells with photoirradiation.

本文言語English
ページ(範囲)28-35
ページ数8
ジャーナルArkivoc
2004
13
出版ステータスPublished - 2004 8 23

ASJC Scopus subject areas

  • Organic Chemistry

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