Molecular design, chemical synthesis, and evaluation of cytosine-carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA

Yusuke Idutsu, Ayaka Sasaki, Shuichi Matsumura, Kazunobu Toshima

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The designed cytosine-carbohydrate hybrid molecule selectively recognized and stabilized the bulged duplex DNA possessing the complementary bulged DNA base, guanine, while the nucleotide base itself did not exhibit any such ability. It was also found that the assistance of the carbohydrate to stabilize the interaction between the nucleotide base and the complementally bulge DNA base is very helpful for the selective recognition and stabilization of the single-bulged duplex DNA.

本文言語English
ページ(範囲)4332-4335
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
15
19
DOI
出版ステータスPublished - 2005 10月 1

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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